Adverse reactions reported since market introduction include very rarely: retinal vein occlusion, stroke, and death associated with venous thromboembolism VTE. In terms evista causing insomnia of bone cycles, this is equivalent to approximately years in humans. See is the most important information should know about Evista? The most common side effects of Evista are hot flashes, leg cramps, swelling of the feet, ankles, and legs, flu syndrome, joint pain, and sweating. Increased risk of death due to stroke occurred in trial in postmenopausal women with documented coronary heart disease or at increased risk for major coronary events. If you have any problems or questions that concern you while taking EVISTA, ask your doctor or pharmacist for more information. Other potential side effects include hot flashes, leg cramps, swelling of the legs and feet, flu-like symptoms, joint pain, and sweating.